Evaluation of prescribing pattern of drugs and compliance to standard treatment guidelines in patients of chronic hepatitis B: a prospective observational study

Background: Hepatitis B is a major global health problem. Chronic hepatitis characterized by hepatic inflammation, necrosis and persistence of HbsAg for at least 6 months. liver disease more predictably associated with impaired metabolism drugs than acute dysfunction. Prescribing in patients chronic challenging because concerns that the drug may exacerbate disease. There also fear altered state change excretion drug. Methods: A cross-sectional prospective study was conducted involving diagnosed clinic outpatient department (OPD) AIIMS Bhopal. total 102 who met inclusion criteria were recruited study. Results: Out prescriptions, 492 prescribed patients. patients, 81 (81.66%) on entecavir monotherapy rest 21 (18.34%) tenofovir disoproxil fumarate (TDF) monotherapy. Of 102-prescription issued, 92.15% (94/102) compliant 7.85% (8/102) noncompliant. Conclusions: Entecavir most common antiviral prescribed, followed B. Spironolactone plus torasemide combination fixed dose used among participants. Liver cirrhosis portal hypertension complication. Majority prescriptions recommendations pharmacotherapy safety guidelines